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Introduction To LAT Antibody

LAT (linker to activate T-cells) is an adaptor phospho-tyrosine 36 kD protein with SH2 domains and a CVRC motif. Two forms of LAT have been discovered with molecular weights ranging from 38 kD and 36 kD. 

LAT is a lipid raft and could also be a transmembrane type III protein believed to be present within the intracellular juxtanuclear compartment. You can know more about Anti-LAT Antibody online.

LAT Antibody (LAT.10-17) (NBP2-00289): Novus Biologicals

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LAT binds TCR engagement to Ras-MAPK activation Ca2+ flux, expression of IL-2, and is essential for the development of T-cells. 

LAT is phosphorylated after activation by TCR cross-linking and activates signaling molecules. LAT activation can be slowed by polyunsaturated fats. LAT is modified by ZAP 70 and Syk the phosphorylation process and maybe palmitoylated.  

LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It also participates with NK cells and their signaling as well as platelet activation.

LAT, which is also known as a linker that activates T cells is a membrane protein, which has been demonstrated to be associated with the PLC G1 protein as GRB2 and the p85 component of PI 3 kinase. 

LAT is believed to be involved in the activation of transcription that is mediated by the AP-1 protein and NFAT in response to activation of the T-cell receptor and suggests that it functions as linker proteins in the activation of T cells.